284 A genome-wide association study of hand eczema in the Dutch general population

Genetic effects play a role in hand eczema (HE), according to population-based twin and candidate gene studies. However, the genetic factors responsible for HE are not fully understood. Therefore, aim of this study was identify characterize loci associated with Lifelines, Dutch general prospective cohort biobank study. The primary analysis consisted 2.789 cases self-reported 12.316 healthy controls without HE, eczema, atopic dermatitis (AD) and/or contact allergy. Secondary analyses were performed, including I) selection less stringent (only no HE), II) case-control matching based on age gender secondary analyses. Genome-wide association studies (GWAS) using logistic regression analyses, adjusted sex, performed all additionally AD. In both we found multiple genome-wide significant single nucleotide polymorphisms (SNPs) at locus 20q13.33. lead SNP (rs8114049) is an intron variant mapping RTEL1 RTEL1-TNFRSF6B genes (p-value = 2.053x10-11). An in-silico look-up revealed that linkage-disequilibrium variants previously diseases. Our also SNPs nearby TNFRSF6B, ZGPAT, SLC2A4RG, ZBTB46, ARFRP1, LIME1 STMN3. All adjustment AD, showed similar genes. conclusion, first has between 20q13.33 independent